Influence of zinc hydroaspartate on the anti-inflammatory and gastric activity of ketoprofen in rats.

BACKGROUND The study's aim was to evaluate the anti-inflammatory effect and influence on gastric mucosa after the combined administration of ketoprofen and zinc hydroaspartate (ZHA, 60 mg/kg). METHODS Antiedematous activity was determined according toWinter et al., analgesic activity according to the Randall and Selitto test, the influence on gastric mucosa in accordance to Komatsu. RESULTS Single and subchronic administration of ZHA and single ketoprofen po caused a significant reduction of the rat hind paw edema in comparison to the control groups. ZHA alone administrated ip four times was active after the 1st, 2nd and 3rd h from the carrageenan injection. CONCLUSIONS ZHA enhanced the anti-inflammatory effect of ketoprofen.